In Single Player campaign, the MP40 is a very common weapon, though it is found in use with Officers and NCO character models in all Allied Assault games, Rarely will regular Troops seek to use it in battle, opting for the Kar98k or opting for MG42 mounted positions.
With its 32-round magazine, it can put out more hurt than the M1A1 Thompson and other SMGs at the cost of higher recoil, the only SMGs out-competing it are the Moschetto with its Ammo Capacity of 40-rounds and the PPSh-41 with its Ammo Capacity of 70-rounds. It has high recoil in comparison to the other SMGs, so this gun should be used just like the BAR. In order to maintain accuracy, the player must burst-fire at medium range, and semi-automatic trigger-tap at long range, though at close range the player may feel free to go full out if they think it's worth it, as power and ROF trump accuracy at close range while it being the exact opposite at long range.
In Medal of Honor: Frontline, it is the same as the one in Allied Assault, but it is rare to find and is only usable in 3 missions, "A Storm in the Port", "Several Bridges too Far", and "Rolling Thunder". It is a decent weapon, while it has less damage than in AA, it has considerably lower recoil. And it's rate of fire and sound is exactly the same as in Allied Assault.
In Medal of Honor: Vanguard, the MP40 is again an obtainable weapon. It is not upgradeable, but is much more common than the Thompson. it has an abnormally faster rate of fire than the M1928 Thompson, with the 2 SMG's rates of fire switched out due to balancing reasons, with the higher fire rate, it also does less damage, though this in turn allows it less recoil, making it more accurate than the Thompson, and as such, is often advised to trade off any rifle. It's not usable only in levels Scavengers, Predators andCrucible.
In the mobile phone version of Medal of Honor: Airborne, the MP40 is used only by the SS Officer, and is one of the strongest weapons in the game, matched only by the Thompson. It cannot be used by the player.